| 학회 |
한국공업화학회 |
| 학술대회 |
2008년 봄 (05/09 ~ 05/10, 한양대학교(안산)) |
| 권호 |
12권 1호 |
| 발표분야 |
나노기술 |
| 제목 |
Synthesis and characterization of temperature sensitive and tumor targeted chitosan nano-carrier |
| 초록 |
The aim of this study is to synthesize and characterize temperature sensitive and tumor targeting chitosan nano-carrier for drug delivery to cancer cell. Chitosan was used as a main body of functional groups which showed temperature-sensitivity, tumor targeting and drug-carrier stealth. N-isopropylacrylamide can lead to form the nanoparticles depending on temperature changing. Folate conjugation may improve drug delivery efficiency due to promoted uptake of folate receptor-bearing cancer cells. And PEGylation can decrease of plasma protein binding and erythrocyte aggregation, and prevent of recognition by the immune system. |
| 저자 |
정유연, 심진기, 이상봉, 조계민
|
| 소속 |
한국생산기술(연) |
| 키워드 |
chitosan; temperture sensitive; drug delivery; tumor targeting
|
| E-Mail |
|
