| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vivo sustained release of protein drugs using small intestinal submucosa |
| 초록 |
Drug delivery systems are capable of maintaining a sustained release of protein drugs for predefined periods, thereby improving its bioactivity and bioavailability. Small intestine submucosa (SIS) is an extracellular matrix and consists of types I and III collagens as well as several biologic factors. The SIS could be prepared as SIS solution via SIS powder through a variety of processing steps. When injected by syringe at the target location, this protein-SIS solution can form a protein-loaded SIS gel that acts as a depot for sustained delivery of the protein drug. BSA-FITC concentrations in rats injected with a BSA-FITC-loaded SIS solution reached a maximum at 9 hours, but exhibited a sustained-release profile, producing detectable levels of BSA-FITC in plasma for up to 20 days. SIS gel did not provoke a significant inflammatory response. This injectable property suggests that the SIS is suitable for use as a minimally invasive therapeutic drug carrier. |
| 저자 |
윤소미1, 강꽃님1, 김다연1, 이봉2, 민병현1, 김재호1, 김문석1
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| 소속 |
1아주대, 2부경대 |
| 키워드 |
drug delivery system; SIS
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| E-Mail |
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