| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
고분자구조 및 물성 |
| 제목 |
Peptide-Driven Self-Assembly of Low-Dimensional DNA Nanostructures |
| 초록 |
Here, we present the rational design and fabrication of unusual low-dimensional DNA nanostructures through programmable and sequence-specific peptide interactions. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino-acid interactions. Moreover, DNA-b-poly(amino acid) assemblies can undergo protease-induced fiber-to-sheet shape transformations, where the morphology change is dictated by the type of enzymes and amino acid sequences. The peptide-based self-assembly reported here provides a programmable approach to fabricate dynamic DNA assemblies with unusual low-dimensional structures. |
| 저자 |
박소정1, Chan-Jin Kim2, Shine K. Albert2
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| 소속 |
1이화여자대, 2Ewha Womans Univ. |
| 키워드 |
self-assembly; block copolymer; DNA; peptide; functional polymer; nanosheet; nanofiber
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| E-Mail |
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