| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The control of cell adhesion by thermally- responsive polypeptides |
| 초록 |
Elastin-like polypeptide (ELP) are thermally responsive artificial biopolymer. They have reversible inverse phase transition temperature (Tt). They are soluble in water below Tt (hydrophilic state) but aggregated when the temperature is raised above Tt (hydrophobic state). Because of this property, they have been studied for stimuli-responsive material. Especially due to their biocompatibility, it has been applied to cell culture in tissue engineering. In this presentation, the property of stimuli-responsive bioactive ELP synthesized by recombinant DNA technique is characterized using UV spectrometer. The adhesion behavior of 3T3 fibroblast which is cultured on ELP coated plate was investigated according to the change of temperature. We will also discuss the relation between the temperature-induced hydrophilic/hydrophobic property alteration and cell adhesion/detachment behavior. |
| 저자 |
김옥진1, 현진호2, 나경아2, 김경철2, 정재연2, 신병철3
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| 소속 |
1서울대, 2바이오시스템소재학부, 3한국화학(연) |
| 키워드 |
elastin-like polypeptide(ELP); reversible inverse phase transition temperature; cell adhesion/detachement
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| E-Mail |
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