| 학회 |
한국재료학회 |
| 학술대회 |
2013년 가을 (11/06 ~ 11/08, 제주롯데호텔) |
| 권호 |
19권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
TTCP-DCPA injectable bone substitute with SiO2 sphere loading to improve mechanical strength and biodegradability and as a drug delivery system |
| 초록 |
Injectable bone substitute consisting of SiO2 micro-particles is developed. Nanostructured and nanocrystallite SiO2 is synthesized from a highly porous matrix of amorphous silica gel. Amorphous silica gel is an incomplete linkage of polysilicic acid. The sol will be obtained by hydrolysis of tetraethyl orthosilicate (TEOS) with an acid catalyst with a molar ratio of water to TEOS of 4. After homogenization by means of ultrasonic treatment, the mixture is spray dried. These are dried quickly in the drying chamber to micro particles. With a further heat treatment at 700°C in air the organic remains are removed from the biomaterial. The micro particles are set to use as granular filler for the proposed IBS. The IBS is prepared by mixing TTCP and DCPA powders with liquid component made of polymeric modifier dissolved in saline water. The particle loaded IBS is expected to have a short degradation time for quick bone regeneration and as nano crystallite filler for enhanced packing density and thus better material performances. Detailed materials properties like setting time and compressive strength would be evaluated. The effect of silica particle incorporation in the IBS system is to be evaluated in terms of setting time change and strengthening aspects as the silica is dissolved quickly and there is a possibility of interaction with the silica phase and the calcium containing phase there by enhancing the setting mechanism to impart positive effect on the setting time and compressive strength. |
| 저자 |
Swapan Kumar Sarkar1, Andrew Reyes Padalhin2, Young Ki Min3, Byong Taek Lee4
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| 소속 |
1Department of Regenerative Medicine; Institute of Tissue Regeneration, 2School of Medicine, 3Soonchunhyang Univ., 4Department of Regenerative Medicine |
| 키워드 |
Injectable bone substitute; Silica particle; Biodegradation
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| E-Mail |
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