| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
Biopolymer-Based Hybrid Materials for Sensing and Delivery |
| 제목 |
Aptide-Nanoparticle Bioconjugates for Targeted Cancer Imaging |
| 초록 |
Aptides, developed by us, are a novel class of high affinity and specificity peptides that offer the potential for use as diagnostic or drug candidates. In this lecture, I will show you a couple of aptide-based biomedical applications using cancer-specific aptides-nanoparticle conjugates. Two cancer-specific aptides (fibronectin EDB- and HER2-specific aptides, respectively) were conjugated with superparamagnetic iron oxide nanoparticles (SPIONs) with the aim of targeted cancer imaging by MRI. In vitro and in vivo experiments revealed that the aptide-SPION conjugates showed specific binding and/or accumulation to target cancer cells and tumors. |
| 저자 |
전상용, 박진호, Phei Er Saw, 김성현, 이인현
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| 소속 |
광주과학기술원 |
| 키워드 |
나노입자; 펩타이드; 암진단; 암치료; 앱타이드
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| E-Mail |
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