| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
WS2 Nanosheet Antipyrotics with Anti-inflammatory and Anti-apoptotic Activities for Wounding Healing |
| 초록 |
Since burn wounds arecomplicated traumas accompanying oxidative stress and impairment of inherentcellular defense mechanisms against external bacteria, it is of greatsignificance to develop new effective topical antipyrotics. Herein, wedeveloped ultrathin WS2nanosheets exfoliated and functionalized with PCL-b-PEG (2H-WS2)in aqueous solution, exhibiting superior scavenging ability and sustainabilityfor a wide range of reactive oxygen species (ROS) and reactive nitrogen species(RNS) in keratinocytes. Also, 2H-WS2 couldinhibit the expression of inflammatory cytokines and promoted the secretion of antioxidative enzymes and antimicrobial peptides in the skin cells. 2H-WS2 nanosheets accelerated skin regeneration by significantly improving thetherapeutic efficacy in the burn wounds of mice. WS2 antipyroticswere emplolyed as an alternate antipyrotic for the treatment ofburns and can be extended for the therapy of other diseases induced byoxidative stress and inflammation. |
| 저자 |
소윤희, 이현지, 이신, 최찬희, 명예솔, 이준형, 신재훈, 김종호
|
| 소속 |
한양대 |
| 키워드 |
anti-inflammation; anti-apoptosis; burn wound healing; oxidative stress suppression; WS2 nanosheet antipyrotic
|
| E-Mail |
|
