| 학회 |
한국재료학회 |
| 학술대회 |
2011년 봄 (05/26 ~ 05/27, 제주 휘닉스 아일랜드) |
| 권호 |
17권 1호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Macrophage Migration on Transparent Titanium Nanostrtructure |
| 초록 |
The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and orthopedic applications. Here, macrophage activation, as evidence of migration, on transparent nanostructured titanium correlated with pro-inflammatory protein synthesis. Through the real-time monitoring of initial cytoskeleton variations, it was identified that macrophage movement was restricted on nano structured titanium compared to flat titanium surfaces. Furthermore, nano structured titanium elicited secretion of less pro-inflammatory enzyme molecules, as well as reduced nitric oxide production. All results collectively indicated that initial macrophage activation can be controlled and minimized by nanoscale surface topography alone, without modification of surface chemistry or stiffness. |
| 저자 |
Soyoung Lee1, Jungil Choi2, Yeon-Min Im3, Ji-Yun Kim4, Sang-Hyun Kim5, Dongwoo Khang6
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| 소속 |
1Department of Pharmacology, 2School of Medicine Kyungpook National Univ., 3Department of Anatomy, 4Institute of Health Science and School of Medicine, 5Gyeongsang National Univ., 6School of Materials Science and Engineering |
| 키워드 |
Immunotoxicity; Nanostructured titanium; Pro-inflammatory protein synthesis
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| E-Mail |
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