| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
PEGylated Melanin Nanoparticles as a Photothermal Therapeutic Agent |
| 초록 |
Melanin has a unique photothermal conversion characteristic, but it does not dissolve in various solvents including physiological fluids. Herein, we attempted to conjugate with poly (ethylene glycol) (PEG) to increase the solubility of melanin and thus improve the availability of biomedical applications. Melanin-PEG nanoparticles had spherical shape with a size of 109.33 nm and showed no precipitation for 7 days. Due to the intrinsic properties of melanin, the Melanin-PEG nanoparticles showed good photothermal conversion efficiencies both in vitro and in vivo. The tumor growth was suppressed post the irradiation following intravenous injection of Melanin-PEG nanoparticles into 4T1-bearing mice. We believe that Melanin-PEG nanoparticles could become an attractive photothermal therapeutic agent for photothermal cancer therapy. |
| 저자 |
김민아, 김예슬, 이호준, 조용준, 박지선, 윤순도, 이창문
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| 소속 |
전남대 |
| 키워드 |
Melanin; Poly (ethylene glycol); Nanoparticles; Photothermal therapy; Cancer therapy
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| E-Mail |
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