| 학회 |
한국공업화학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
8권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Thermosensitive Nanoparticles Formed by Self-assembly of Poly(N-isopropylacrylamide)-Poly(ε-caprolactone) for Drug Delivery System |
| 초록 |
To invest thermosensitivity on polymeric amphiphiles, the poly(N-isopropylacrylamide)-b-poly(ε-caprolactone) block copolymers (PNPCL) with different PCL block length were synthesized by hydroxyl-terminated poly(N-isopropylacrylamide) (PNP-OH) initiated ring opening polymerization of ε-caprolactone. Thermosensitive nanaparticles formed by self-assembly of PNPCL in aqueous environment, were prepared by a solvent evaporation method and their physicochemical characteristics were investigated. The nanoparticles showed PCL block length dependent physicochemical properties such as particle size, critical aggregation concentration, and inner core hydrophobicity. Furthermore, the PNPCL nanoparticles showed typical thermosensitivities, such as particle size and optical transmittance changes by increasing temperature, owing to the unique extended coil to globule transition of PNP shells. Then, the thermosensitive nanoparticles were introduced into drug delivery systems using hydrophobic model drug of clonazepam (CNZ). |
| 저자 |
최창용1, 김태형1, 채수영1, 김동곤1, 장미경1, 정창남1, 조종수2, 나재운1
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| 소속 |
1순천대, 2서울대 |
| 키워드 |
Nanoparticle; Thermosensitivity
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| E-Mail |
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