| 학회 |
한국공업화학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
8권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Thermosensitive Nanoparticles Formed by Self-assembly of Poly(N-isopropylacrylamide)-Poly(ε-caprolactone) and Poly(ethylene glycol)-Poly(ε-caprolactone) Block Copolymers for Drug Delivery System |
| 초록 |
To prepare nanoparticles, which are thermosensitive, biocompatible, and biodegradable, the well-defined PNIPAAm-PCL and PEG-PCL block copolymers were synthesized by ring-opening polymerization of e-caprolactone using mPEG-OH and PNIPAAm-OH and characterized by 1H-NMR and GPC. Thermosensitive nanaparticles according to various ratios of PNIPAAm-PCL and PEG-PCL were prepared by a solvent evaporation method. The nanoparticles showed composition dependent physicochemical properties such as lower critical solution temperature, particle size, and critical aggregation concentration. Then, the nanoparticles were introduced into drug delivery systems using hydrophobic model drug of clonazepam. The drug release behaviors from nanoparticles were investigated. |
| 저자 |
최창용1, 김태형1, 채수영1, 김금진1, 김동곤1, 권중근2, 나재운1
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| 소속 |
1순천대, 2조선이공대 |
| 키워드 |
Nanoparticle; Thermosensitivity
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| E-Mail |
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