| 학회 |
한국화학공학회 |
| 학술대회 |
2005년 봄 (04/22 ~ 04/23, 여수대학교) |
| 권호 |
11권 1호, p.27 |
| 발표분야 |
고분자 |
| 제목 |
Application of Thermosensitive Nanoparticles using Poly(N-isopropylacrylamide-b-ε-caprolactone) and Poly(ethylene glycol-b-ε-caprolactone) |
| 초록 |
To endow polymeric nanoparticles with thermosensitive, biocompatible, and biodegradable characters, nanoparticles composed with poly(N-isopropylacrylamide-b-ε-caprolactone) (PNIPAAm-PCL) and poly(ethylene glycol-b-ε-caprolactone) (PEG-PCL) block copolymers were prepared with different the block copolymer compositions. The nanoparticles showed composition dependent physicochemical properties such as lower critical solution temperature, particle size, and critical aggregation concentration. Then, the nanoparticles were introduced into drug delivery systems using hydrophobic model drug of clonazepam. The temperature sensitive drug release behaviors from nanoparticles were investigated. |
| 저자 |
최창용1, 채수영1, 공병기1, 장미경1, 조종수2, 나재운1
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| 소속 |
1순천대, 2서울대 |
| 키워드 |
Thermosensitivity; nanoparticle; Drug delivery system
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| E-Mail |
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| 원문파일 |
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