| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Heparinized Chitosan-Pluronic® Hydrogel with Thermosensitivity for Controlled Growth Factor Delivery |
| 초록 | It has been reported that the growth factor plays a critical role as an induction agent of some important mediators for tissue regeneration. A number of growth factors specifically bind to heparin with a high affinity, and both its mitogenic activity and biological stability are modulated by heparin. Heparin also protects growth factors from inactivation and degradation by some external stimuli. Therefore, heparin-containing biomaterials have a lot of potential as the controlled delivery vehicle for the growth factors with the useful bioactivities. In our previous study, a thermosensitive Pluronic® grafted chitosan (chitosan-Pluronic®) as an injectable hydrogel has been deveoloped. In this study, heparinized chitosan-Pluronic® as an injectable hydrogel has been prepared for the long-term controlled release of heparin-binding growth factors. Chitosan-Pluronic®-heparin complex has demonstrated the sol-gel transition behavior, the enhanced gel stability and growth factor affinity. This novel thermosensitive hydrogel would be very effective for growth factor delivery as well as cell-supporting scaffold for tissue regeneration. |
| 저자 | 고동현1, 이준우2, 박기동1 |
| 소속 | 1아주대, 2한국과학기술정보(연) |
| 키워드 | chitosan; heparin; thermosensitive; hydrogel |
