| 초록 |
Pullulan has been widely investigated in the biomedical applications due to their diverse physiochemical properties, enhanced biocompatibility and biodegradability and minimized toxicology profiles. In this study, we made antiadhesive solution for postoperative tissue adhesion barrier with stickiness property of pullulan. And, we mixed the CMC to increase the viscosity and also to increase the time that the barrier stays on the wound site where adhesion will occur. Further, we blended Pullulan/CMC with Pluronic F127 (F127) in different ratios from solution to develop thermosensitive injectable hydrogels. Later, we studied the in vitro toxicology profiles of Pullulan/CMC barrier solution and Pullulan/CMC/F127 injectable hydrogels. Further, we studied in vivo therapeutic efficacy Pullulan/CMC barrier solution and Pullulan/CMC/F127 injectable hydrogels. In conclusion, we believe that our product.could prevent the postoperative tissue adhesions with enhanced stability and biocompatibility. |
