| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Effect of inorganic additives in PLGA implants for bone tissue engineering |
| 초록 |
Poly(lactic-co-glycolic acid) (PLGA) has attracted considerable interest as a material for bone tissue engineering due to proper mechanical properties. However, PLGA during manufacturing underwent thermal decomposition and thus formed acidic degradation products. When thermally degraded PLGA was implanted into a target tissue such as bone, the pH in surrounding tissues decreased and inflammatory reaction was occurred. In this study, we have prepared the PLGA composites with inorganic additives including Mg(OH)2 and ß-TCP as a pH neutralizing agent to inhibit the accumulation of acidic byproducts and accordingly suppress inflammation and a bone graft material, respectively. Such PLGA/inorganic additive composites were prepared with a twin extruder and characterized by FE-SEM, TGA, GPC, and UTM. |
| 저자 |
이슬기1, 이유진1, 김익환2, 정윤기1, 한동근1
|
| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
bone graft; PLGA; magnesium hydroxide; beta-tricalcium phosphate
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| E-Mail |
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