| 초록 |
Nanodiamonds (NDs), carbon nanoparticles with a truncated octahedral architecture, have been paid increasing attention as a promising material in nanomedicine due to their spherical morphology, versatile functionality, fluorescent property, colloidal stability, and high biocompatibility. ND clusters are conjugated with folic acid (FA) and doxorubicin (Dox) via carbodiimide chemistry (FA/Dox-ND clusters). Cell experiments revealed that KB cells are preferentially ablated by FA/Dox-ND clusters compared to A549 cells. In vivo results revealed that FA/Dox-ND clusters are specifically accumulated in tumor tissues after intravenous injection into tumor-bearing mice, effectively reducing the volume of tumor. Based on these results, this study suggests that FA/Dox-ND clusters can be a good candidate as tumor-targeted nanovehicles for delivery of antitumor drug. |
