| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
ROS-responsive and PD-L1 targeted Thioketal Nanoparticles Triggered Mitochondrial-mediated Apoptotic Cell Death in Melanoma Model |
| 초록 |
Melanoma (MEL) is characterized by high PD-L1 expression and hypoxic tumor environment. Hypoxic condition promotes reactive oxygen species (ROS) production and this could be a target for MEL. In this study, we have prepared PD-L1 targeted and temozolomide-loaded ROS-responsive thioketal nanoparticles (anti-PD-L1-TMZ-TKNPs) for treatment of MEL. Anti-PD-L1-TMZ-TKNPs was successfully constructed with the particle size of 103.2 ± 1.6 nm and zeta potential of -12.9 ± 0.3 mV. The release study showed that 80% of TMZ was released at 48 h from anti-PD-L1-TMZ-TKNPs with 1 mM H2O2 at acidic pH suggested the ROS-responsive behavior. In B16F10 xenograft mice model, maximum distribution with a significant decrease in tumor volume was observed after intravenous injection of anti-PD-L1-TMZ-TKNPs. In conclusion, anti-PD-L1-TMZ-TKNPs offers the targeted and ROS-responsive release of TMZ for treatment of MEL. |
| 저자 |
Asmita Banstola1, Simmyung Yook2
|
| 소속 |
1College of Pharmacy, 2Keimyung Univ. |
| 키워드 |
Melanoma; Reactive oxygen species; Thioketal nanoparticles; Hypoxic; Normoxic
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| E-Mail |
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