| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Fabrication of Cross-linked Alginate Beads Using Electrospraying for Adenovirus Delivery |
| 초록 |
Cross-linked alginate beads containing adenovirus (Ad) were successfully fabricated using an electrospraying method to achieve the protection and release of Ad in a controlled manner. An aqueous alginate solution containing Ad was electrosprayed into an aqueous phase containing a cross-linking agent (calcium chloride) at different process variables (voltages, alginate concentrations, and flow rates). In vitro results of gene expression revealed that the Ad encapsulated in the alginate beads with 0.5 wt% of alginate concentration exhibited a high activity for a long period (over 7 days) and was released in a sustained manner from the alginate beads. The Ad-encapsulating alginate beads could be promising materials for local delivery of Ad at a high concentration into target sites. |
| 저자 |
박홍관1, 김평환2, 황태원1, 권오준2, 박태준1, 최성욱3, 윤채옥2, 김중현1
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| 소속 |
1연세대, 2한양대, 3가톨릭대 |
| 키워드 |
electrospraying; encapsulation; adenovirus; alginate; controlled release
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| E-Mail |
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