| 초록 |
Dopamine is one of biomolecule which undergoes self-polymerization in basic aqueous solution without any other reagent. However, during the oxygen-demanding situation; such as exponential growth of E. coli, self-polymerization of dopamine is almost inhibited. In contrast, polydopamine is formed during steady-state growth of bacteria because oxygen is abundant in the solution. This polydopamine-oxygen relationship is further demonstrated by using fluorescent dextran nanoparticles (FDNPs) as sensors, whose fluorescence is quenched by polydopamine formation. The fluorescence character of FDNP can be modulated by dopamine concentration, incubation time, and the number of bacteria. In addition, it is possible to use the strong relationship between bacterial growth, oxygen level, polydopamine, and fluorescence for the detection of antibiotic-resistant bacteria. |
