| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Photodynamic Therapy for treat acnes using nanoparticles which loaded polymer conjugated photosensitizer to enhance of skin penetration. |
| 초록 | In recent years, Photo Dynamic Therapy (PDT) has been proposed their potentials to treat acne using Photosensitizer(PS) or PS-conjugated drugs. However, drug resistance and side-effects are acting as barriers in their bio-application. In this study, we solve these problems to fabricate nanoparticles which loaded polymer-conjugated PS for enhencing skin cell penetration. After irradiation of specific wavelengh, there are remarkable results in PS loaded nanoparticle group. Using Franz cell diffusion system, we compare the tissue penetration efficiency between free PS and PS loaded nanoparticles. As a result, PS loaded nanoparticles group has higher skin permeability than free PS group. In addition, PS loaded nanoparticles group exhibited the 2-fold, 1.5–fold higher toxicity of acnes than conventional antibiotics group and PS conjugated with cationic polymers group. Consequently, PDT with PS loaded nanoparticles is effective for the treatment of acnes. |
| 저자 | 김홍재, 박혜진, 박형, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Nanoparticle; skin penetration; Acnes |
