| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 |
18권 1호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Optimizing gene and peptide co-delivery system of ternary complexes via receptor mediated endocytosis for cancer therapy |
| 초록 |
The aim of this study was to deliver gene and peptide for synergetic action against tumor. The ternary complexes of gene, peptide, and targeting peptide conjugated-LMWSC were prepared by electrostatic interaction in aqueous solution. The binding affinity of ternary complexes were confirmed by electrophoresis. The particle size of them was evaluated by DLS. The result of tranfection assay showed that ternary complexes with LMWSC-targeting peptdie was more effective than that without peptide for targeting of cancer cell. The cytotoxicity and antitumor activity of ternary complexes were confirmed by MTT assay. These results suggest that ternary system can effectively inhibit tumor growth. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education. Science and Technology (NRF-2012R1A2A2A01014898). |
| 저자 |
정경원, 박순정, 김남홍, 박성철, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
gene; peptide; LMWSC-targeting peptide
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| E-Mail |
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