| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 | 13권 2호, p.1653 |
| 발표분야 | 분리기술 |
| 제목 | Conversion of L-ribose from L-arabinose by Epimerization and Determination of the Epimerization Conditions by Ion Exchange Chromatography and HPLC |
| 초록 | The use of L-carbohydrates and their corresponding nucleosides in medicinal application has greatly increased. For example L-ribose has been much in demand as the starting material for curing hepatitis B. However, L-ribose dose not occur in nature. L-ribose was reported to be produced by epimerization. Bilik published a simple synthesis of L-ribose by molybdate-catalyzed epimerization of the readily available L-arabinose in 1973. The reaction now is known as the Bilik reaction. In this study, the effects of the temperature, solvent, reaction time and molybdenum(Ⅵ) oxide amount on epimerization were examined by measuring the product concentration in sugar HPLC column. In addition, conversion mixture of L-ribose, L-arabinose, and MoO3 was separated by using ion exchange cloumn packed by Dowex ca resin. Acknowledgement This research was supported by Korea Energy Management Corporation. |
| 저자 | 전영주, 김인호 |
| 소속 | 충남대 |
| 키워드 | L-ribose; Epimerization; HPLC |
| 원문파일 | 초록 보기 |
