| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
정밀화학_포스터 |
| 제목 |
Synthesis and initial in vivo evaluation of [125I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for SPECT imaging of apoptosis |
| 초록 |
The purpose of this study was to synthesize 125I-labeled 2-(4-iodophenethyl)-2-methylmalonic acid ([125I]IMA) and its biodistribution study for the development of new apoptosis imaging tracer. The optimized radiolabeling procedure provided [125I]IMA with high radiochemical yield (75.5 ± 5.2%) and excellent radiochemical purity (＞99%) within 100 min. Specific radioactivity of [125I]IMA was observed to be 31.0 MBq/mol. Ex vivo biodistribution study of [125I]IMA was carried out using male ICR mouse and the result showed the uptake values in apoptotic cells of the testes of the male mice were more than 1.7 fold higher than those of leg muscle. Those results demonstrated that [125I]IMA will be a potentially useful radiotracer for in vivo imaging of apoptotic cell and tissue. |
| 저자 |
Sajid Mushtaq, 전종호
|
| 소속 |
한국원자력(연) |
| 키워드 |
radiolabeling; radiotracer; molecular imaging; apoptosis
|
| E-Mail |
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