| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
정밀화학 |
| 제목 |
Synthesis of 125I-labeled tetrazine for rapid and efficient radiolabeling of trans-cyclooctene group bearing biomolecules |
| 초록 |
Herein, we present a rapid and efficient radiolabeling method of trans-cyclooctene (TCO) group conjugated biomoleculs using 125I-labeled tetrazine analog. For this study, radioiodination of the stannylated precursor 2 was carried out at ambient temperature to give ([125I]1) with high radiochemical yield (65±8%) and radiochemical purity (＞99%). As a radiolabeling application of ([125I]1), TCO-derivered human serum albumin (HSA) was reacted with [125I]1 under mild condition to yield the radiolabeled product [125I]3 with a high radiochemical yield (＞99%). We next carried out the tissue biodistribution study of [125I]3 in normal ICR mice to investigate the level of organ accumulation profile. The biodistribution of [125I]3 showed significantly lower thyroid uptake values than that of 125I-labeled HSA ([125I]4) prepared by a direct iodine labeling method. Therefore [125I]3 will be used as a quite promising radiotracer for the various biomedical and imaging study. |
| 저자 |
최미희, 심하은, 전종호
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| 소속 |
한국원자력(연) |
| 키워드 |
Radiolabeling; Radioactive iodine; Radiotracer; Invers-electron-demand Diels-Aler reaction
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| E-Mail |
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