| 초록 |
Endocrine-disrupting chemicals (EDC) leached from plastic wastes include bisphenol A, flame retardants, phthalates that mimic the structure or function of natural hormones. However, their potential impacts on the ecosystem are not well understood. Accordingly, there is a lack of tools that can deactivate the toxic activities of EDCs. This talk will address this challenge by covering emerging efforts of engineering fish organoids that can recapitulate the structure and physiological activities of organs and tissue of interest. In particular, we will introduce how to engineer zebrafish liver organoids that can detoxify EDCS naturally to protect other organs and further predict in vivo responses to EDCs precisely. Additionally, we will present a catalyst system we developed to deactivate EDCs and evaluate their function using the liver organoid. Overall, this talk will deliver essential insights on both evaluation and treatment of EDCs. |
