| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization ofkeratin/PLGAhybrid scaffold for tissue engineered articular cartilage |
| 초록 |
Biodegradable keratins have been widely used to construct scaffolds for cartilage tissue engineering. We examined the effect of Keratin/poly(lactic-co-glycolic acid)(PLGA) scaffold for chondrogenesis. Keratin/PLGA scaffolds were prepared by solvent casting/salt leaching method. All scaffolds were characterized using SEM. Cell proliferation activity was measured by MTT test. Scaffold mechanical strength, histology, gene expression, sulphated-glycosaminoglycan(sGAG) and collagen contents analyses were performed to elucidate in vitro cartiliage development. This study suggests that in vitro chondrogenesis was improved in PLGA scaffolds containing keratin. This research was supported by SCRC(SC4100) and KMOHW(0405-BO01-0204-0006). |
| 저자 |
김수진, 김순희, 홍현혜, 김혜린, 유일수, 이동원, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
Keratin/PLGA scaffold; cartilage; in vitro regeneration; mechanical srength
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| E-Mail |
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