| 초록 |
Immune cell-based therapy has become a powerful method to treat cancer in current clinical studies. In particular, due to the potential to enhance immune responses, adoptive T cell therapy has been widely used. Especially, CD4 T cells, known as helper T cell, are important to adaptive immunity. However, Common anti-cancer therapy has limitations. Firstly, activity of cells is often reduced when cultured in vitro. Secondly, long term retention of transplanted cells in approiate places is hard to achieve. To address these problems, we developed a surface modification technique immobilizing anti-CD4 antibody to PLGA nanofibers. We then measured CD4 T cell isolation efficiency and cultured immune cells on the nanofibers to observe their proliferation and release. In the result, our nanofiber platform could separate CD4 T cells from immune cell mixture and maintained anti-cancer immune cell activity. Therefore, our study can be further applied for adoptive T cell therapy. |
