| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Surface modification of poly (L-lactide-co-ε-caprolactone) nanofibers with gelatin and their effects on cellular responses of human mesenchymal stem cells. |
| 초록 |
Extracellular matrix (ECM) which consists of various proteins and polysaccharides is responsible for maintaining many cellular activities. Recently, electrospinning method has been used to mimic the structural properties of ECM. Surface modifications of synthetic polymers have been applied to control cell function effectively and to improve cell-substrate interactions. In this study, we developed gelatin-modified poly(L-lactic acid-co-ε-caprolactone) (PLCL) nanofiber to mimic structural and functional properties of ECM. The cellular function on the nanofiber was examined using human mesenchymal stem cells (hMSCs). Cellular responses on the gelatin-modified PLCL nanofiber were significantly increased with respect to cell adhesion and proliferation. In addition, differentiation of hMSCs was accelerated on the gelatin-modified PLCL nanofiber. These results indicate that the biomimetic materials may provide a useful strategy for designing an ideal scaffold for tissue engineering. |
| 저자 |
염정석1, 신영민1, 임윤묵2, 신흥수1
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| 소속 |
1한양대, 2한국원자력(연) |
| 키워드 |
surface modification; PLCL; nanofiber; gelatin; human mesenchymal stem cell
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| E-Mail |
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