| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Spatially-controlled Delivery of Cyclodextrin-based Polyplexes from Solid Surfaces |
| 초록 |
The spatially-controlled delivery of growth factor is required for creating a well-organized, complex cellular architecture by tissue engineering. Non-viral gene delivery vehicles have been immobilized to solid surfaces by physical absorption, biotin-streptavidin interaction, and chemical conjugation. Here, we present a new approach for surface-mediated gene delivery based on inclusion complex formation between the solid surface and delivery vehicles. Cyclodextrins form inclusion complexes with small, hydrophobic compounds such as adamantane. In this work, nanoparticle composites of cyclodextrin polycations and nucleic acids were specifically immobilized on adamantane-coated surfaces. The interaction was characterized by surface plasmon resonance (SPR) spectroscopy and by AFM. |
| 저자 |
박인규1, Horst A. von Recum2, Shaoyi Jiang3, Suzie H. Pun4
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| 소속 |
1전남대, 2Univ. of Washington, 3Seattle WA 98195, 4USA |
| 키워드 |
Cyclodextrin-modified polyethylenimine; adamantane; Surface Plasmon Resonance; Inclusion body complex
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| E-Mail |
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