| 학회 |
한국공업화학회 |
| 학술대회 |
2006년 봄 (05/12 ~ 05/13, 전북대학교) |
| 권호 |
10권 1호 |
| 발표분야 |
촉매 |
| 제목 |
Synthesis of Optically Pure α-Aryloxy Alcohols via Kinetic Resolution of Terminal Epoxides with Phenols Promoted by Heterometallic Salen Complexes |
| 초록 |
Enantiopure α- aryloxy alcohols are key synthetic intermediates in a variety of pharmaceutically important compounds. The highly enantioselective kinetic resolution of racemic terminal epoxides with phenols and their derivatives catalyzed by heterometallic chiral (salen)Co-AlCl3 is proven very efficient method for the synthesis of optically pure α-aryloxy alcohols (up to ＞99% ee). The system is conveniently carried out at ambient temperature and provides one pot synthesis. The presence Lewis acid AlCl3 assisted the chiral Lewis acid Co and exhibit strong synergistic effect during catalytic process. A plausible mechanism is proposed that rationalizes the stereochemical outcome of the reaction. |
| 저자 |
라울, 산토스 싱 타쿠르, 김건중
|
| 소속 |
인하대 |
| 키워드 |
heterometallic (salen)Co-AlCl3 complex; kinetic resolution; Lewis acid; α-aryloxy alcohols; terminal epoxides
|
| E-Mail |
|
