| 초록 |
The control of stereoselectivity has been one of the central goals in synthetic organic chemistry due to the presence of chiral molecules in a wide range of natural products and pharmaceuticals. Despite remarkable advances in asymmetric synthesis, the development of catalyst-controlled processes that precisely control relative and absolute configurations of multiple stereocenters is a persistent challenge. In this seminar, I describe a method for the stereodivergent carbon-carbon bond formation catalyzed synergistically by two chiral organocatalysts that furnishes 1,5-aldehydes esters containing two adjacent stereocenters. By altering the relative chirality of catalyst combinations, all four stereoisomers of the products are accessible with high enantio- and diastereoselectivity. |
