| 초록 |
Dual functional low molecular chitosan derivative (LMC) was prepared by introducing phosphate and azido group to LMC (Az-P-LMC). Az-P-LMC has two properties, which are adherable to titanium and photo-curable. The titanium-adherable property of Az-P-LMC promote cell adhesion to titanium surface. Also, Az-P-LMC could immobilize the protein because of the photo-curable property by azido group. The phosphate and azido group of Az-P-LMC was confirmed using 31P-,1H-NMR. Adherable and photo-curable properties were evaluated by cell attachment test and photo-curing test. Also, for medical application, cytotoxicity test was proceeded by WST assay. And for checking the capacity of drugs immobilization, the protein releasing test was carried out. |
