| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and evaluation of novel chondroitin sulfate-based hydrogel |
| 초록 |
The chondroitin sulfate is a biological polymer that is abundant in the extra-cellular matrix(ECM) of connective tissues such as cartilage and tendons. It is long unbranched polysaccharide consisting of alternating disaccharide repeating units of D-glucuronic acid and D-N-acetylgalactosamine. The modification of chondroitin sulfate was performed by EDC-mediated coupling reaction. The chondroitin sulfate hydrogel was processed through a Michael type addition reaction between the grafted acrylates and poly(ethyle oxide)-thiol end groups. We evaluated its gelation time, swelling ratio, release behavior of model drugs and biological properties of a chondroitin sulfate hydrogel. |
| 저자 |
조성연, 김도연, 우정훈, 김수미, 조선영, 황윤재, 오승진, 신철호, 신은경, 소미진, 김현아, 노인섭
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| 소속 |
서울산업대 |
| 키워드 |
chondroitin sulfate; hydrogel; poly(ethylene) oxide; evaluations
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| E-Mail |
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