| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Versatile Surface-coatable IR825-conjugated Fluorescent Polymer as a Dual-functional Biosensor for Synergistic Detection and Eradication of Bacteria |
| 초록 |
We designed a versatile dual-functional biosensor for sensing and killing bacteria by combining cationic fluorescent polymer with NIR-responsive IR825 and adhesive catechol moieties. PVP polymer was quaternized with catechol and bromoethane to obtain adhesive cationic polymer, followed by conjugating fluorescent dye BODIPY and IR825 (F/PVP-IR825). The fluorescence of F/PVP-IR825 was quenched when interacted with bacteria due to ionic interaction between positive charge of F/PVP-IR825 and negative-charged bacteria cell wall. Moreover, this material can be applied in both solid- and liquid-phase assay due to the presence of catechol in F/PVP-IR825. This material also can directly kill bacteria under NIR irradiation because of generation of photothermal heat from IR825. Thus, this approach provides a promising strategy on synergistic bacteria detection and killing which is simple, rapid, and versatile. This work was supported by Korea National University of Transportation in 2018. |
| 저자 |
Akhmad Irhas Robby, Sung Young Park
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| 소속 |
한국교통대 |
| 키워드 |
Fluorescent polymer; catechol; IR825; surface-coatable material; bacteria detection; photothermal heat
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| E-Mail |
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