| 초록 |
Poly(vinyl alcohol) (PVA) with biocompatibility have been widely used as biomedical materials such as drug delivery materials, embolic materials, injectable hydrogels, and so on. Especially, PVA particle used for therapeutic embolization, which is much less invasive than conventional open surgery, is well-established tool in the biomedical industries. To maximize biomedical functionality of PVA particles as embolic materials, syndiotacticity, degree of saponification, and molecular weight which control physical properties of PVA should be increased. Poly(vinyl pivalate) (PVPi) microspheres obtained by low temperature suspension polymerization of vinyl pivalate (VPi) were converted to PVA/PVPi skin/core microspheres through a series of heterogeneous surface-saponification, maintaining their spherical morphology. These microspheres were uniformly spherical in shape and smooth in appearance. To examine the in-vivo property of prepared PVA/PVPi skin/core microspheres and to compare them with commercial PVA embolic materials, the in-vivo experiments were conducted. The mixture of high molecular weight PVA and drug, diclofenac was agitated with high speed by high-pressure homogenizer in order to reach nano size. Prepared Drug-loaded PVA nanoparticles in this experiment are expected as a powerful candidate for the various drug delivery systems. |
