| 초록 |
In this work, we reported on-off switchable imaging using dual pH/redox-sensitive IR825-loaded fluorescent carbon dot (FNP[IR825]) for controlled photothermal (PTT) effect. FNP[IR825] can be successfully entered tumor site, that benzoic imine bonds broke down under acidic cancerous conditions and disulfide bonds are then reduced in glutathione (GSH), subsequently released therapeutic IR825. After the IR825 is released, the NIR laser are utilized for PTT effect that can efficiently perform cancer treatment through photothermal conversion. The system has shown its potential to be used for monitoring in selectively cancer cell fluorescent on/off mediated diagnosis and therapy. |
