| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
Anticancer drug grafted chitosan with target ligand for anticancer drug delivery |
| 초록 |
In this study drug-conjugated chitosan (Chito-Drug) was synthesized by hydrazone bond. The hydrazone bond of Chito-Drug can be dissociated the drug from Chito-Drug at endosomal pH (pH 5.0). In addition, the synthesized Chito-Drug was conjugated the target ligand (TCD) to achieve receptor-mediated endocytosis. Chemical structure of TCD was investigated by FT-IR and 1H-NMR. Its antitumor activity was evaluated by MTT assay against cancer cell. The TCD proposed that the conjugated drug was easily released by hydrazone bond from endosome and effective to target tumor cells. This research was supported by basic science research program through the national research foundation of korea (NRF) funded by the ministry of education. Science and technology (NRF-2012R1A2A2A01014898). |
| 저자 |
김태훈, 박준규, 남정표, 최창용, 박성철, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
pH-sensitive drug release; FT-IR; 1H-NMR; lysosomal pH.
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| E-Mail |
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