| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Poly(2-isopropenyl-2-oxazoline) for Immunotherapeutical Applications |
| 초록 |
Poly(2-oxazolines) represent the group of biocompatible polymers with defined structures with the potential towards different biomedical applications. Poly(2-isopropenyl-2-oxazoline) (PIPOx) is a special member of this group, since it can be prepared by free-radical polymerization of 2-isopropenyl-2-oxazoline, which is proceeding on vinyl group and the reactive 2-oxazoline unit remains on the side chain. This polymer can be used for further functionalization and modification with biologically active substances as proteins, polysaccharides, or drugs. In this work, cytotoxicity and immunotoxicity of prepared PIPOx polymers was assessed using the cell viability MTT test and ELISA assay monitoring the expression of cytokines. We demonstrated that PIPOx has immunomodulatory properties and can specifically modulate the immune response. Acknowledgment: Authors are thankful to VEGA for financial support in the project Nr. 2/0124/18 and SRDA in the project Nr. SK-KR-18-0011. |
| 저자 |
Zuzana Kroneková1, Monika Majerčíková2, Ema Paulovičová1, Lucia Paulovičová2, Juraj Kronek3
|
| 소속 |
1Polymer Institute, 2Slovak Academy of Sciences, 3Institute of Chemistry |
| 키워드 |
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| E-Mail |
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