| 초록 |
Marine mussel adhesion is known to be mediated by mussel adhesive proteins (MAPs), which are secreted through the mussel byssus and have great potential as biologically and environmentally friendly biomaterials due to their biocompatibility and biodegradability. In addition, MAPs have strong adhesion ability even on wet surfaces due to unique amino acid arrangements and composition. However, researches using the natural amino acid composition of MAPs have been limited because of difficulties in obtaining sufficient quantities of MAPs for applications. Recently, we successfully and massively produced genetically redesigned new fusion MAP using a bacterial expression system, and this fusion protein showed significant adhesion ability. In addition, using the superior cell adhesion properties and fusion technology of the bioactive extracellular matix (ECM) peptides, we discovered the great potential of MAPs as bio-functional biomaterials for tissue engineering applications. |
