| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Improved DNA vaccination by concurrent delivery of DNA and chemostatic peptide using microsphere/polyplex-releasing multi-layered microneedle arrays |
| 초록 |
The approach of gene delivery with microneedles has recently been withdrawn much attention. Despite superior capability of microneedles delivering DNA into the dermal tissues, release and cellular uptake of the released DNA after microneedle-based administration have not been clearly studied. In this study, we fabricated polyplex-releasing multilayered microneedles additionally coated with microspheres containing a chemo-attractant for recruiting professional antigen presenting cells such as macrophages. The microspheres can be released from the needle body and localized in the dermis area where chemo-attractant slowly released. The ability of the microneedle-based cutaneous gene delivery system for attracting antigen presenting cells and improving DNA vaccination was tested. |
| 저자 |
정지훈 |
| 소속 |
성균관대 |
| 키워드 |
DNA vaccine; microneedle; layer-by-layer coating; chemostatic peptide; gene delivery
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| E-Mail |
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