| 초록 |
Gene therapy has great potential as a promising therapeutic approach for cancer therapy. Recently, photochemical internalization (PCI) has provided the opportunity to overcome endo-lysosomal sequestration, which is one of the main bottlenecks in both gene and chemotherapeutic delivery. Despite PCI having shown great potential in gene delivery systems, it still remains difficult to perform due to the photo-oxidation of exogenous cargo genes by reactive oxygen species (ROS) generated from activated photosensitizers. In this syudy, a new type of a stable light-triggered gene delivery system is demonstrated based on endo-lysosomal pH-responsive polymeric PSs, which serve as shielding material for the polymer/gene complex. By taking advantage of the endo-lysosomal pH-sensitive de-shielding ability of the pH-responsive shielding material incorporated in the ternary gene complexes, a more signifi cant photo-triggered gene expression effect is achieved without damage to the gene from ROS. |
