| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
(생물공학) 단백질공학의 최신 동향 |
| 제목 |
면역보강제를 포함한 재조합 단백질 백신의 안정화 |
| 초록 |
Proteins of pathogens whether prepared as inactivated viruses/bacteria or recombinantly produced can potentially act as vaccines. However, a recombinant protein alone is usually not immunogenic enough to evoke meaningful antibody production in human bodies, which leads to the formulation with a proper adjuvant. Currently, either aluminum hydroxide or aluminum phosphate is used in the most of adjuvanted vaccines in the market. Considering that the both aluminum salts are prone to aggregation upon freeze in the cold chain, the vaccine formulations with aluminum salts can be greatly stabilized in the absence of water. Since proteins in general become more stable upon heat shocks as well when they are in a solid state drying approaches in vaccine formulation can also be justified. As a part of continued efforts to prove the concept, here we report the stabilization and characterization of Ebola glycoprotein adjuvanted with aluminum hydroxide by lyophilization. |
| 저자 |
강택진1, Carly Fleagle Chisholm2, Axel Lehrer3, Theodore W. Randolph4
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| 소속 |
1동국대, 2Univ. of Colorado, 3Boulder, 4Univ. of Hawaii |
| 키워드 |
Adjuvant; Aluminum salt; Vaccine; Lyophilization
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| E-Mail |
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