| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.384 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and Characterization of Swelled Small Intestinal Submucosa (SIS) sheet for Wound Healing |
| 초록 | The main effect of most skin substitutes is to promote wound healing by stimulating the host to produce various cytokines. These cytokines promote healing by stimulating the production of components in the basement membrane, so preventing dehydration and increasing inflammation, and promoting the formation of granulation tissue. Porcinal small intestinal submucosa (SIS) has been shown to be rich in components which support angiogenesis such as fibronectin, glycosaminoglycans, several collagens and angiogenic growth factors which induce site-specific tissue remodeling. The wound improves healing activity and feels comfortable when the wound area shows the weak acidity. So, for SIS sheets having the weak acidity, we prepared SIS sheets swelled by 1% acetic acid with shaking for 24 hours at room temperature. Until the pH of DW was about 5.5, SIS sheets were washed by DW over 10 times. To enhance of strength of swelled SIS sheets, we were performed that crosslinking using various concentration of 1-ethylene-3-(3-dimethylaminopropyl) carboiimide hydrocholoride (EDC) for 24 hrs1. And we prepared SIS sheets by spreading and freeze-drying. The prepared SIS sheets were evaluated their characteristics such as water uptake ability, surface morphology, in vitro degradation test and in vitro test using NIH/3T3 fibroblast cell line. From this study, swelled SIS is regarded as an appropriate biodegradable material able to dress the wound like a burn in substitution of the traditional artificial composite materials the expected to be used as the biological dressings. Acknowledgement : This work was supported by Korea Ministry of Commerce, Industry and Energy (N11-A08-1402-05-1-3). Reference 1. J.S. Pieper, A. Oasterhof, P.J. Dijkstra, J.H. Veerkamp, and T.H. van Kuppevelt, Biomaterials, 20, 847 (1999) |
| 저자 | 김선화1, 홍금덕1, 신혜원1, 김문석2, 조선행2, 강길선1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | small intestinal submucosa; swelling; sheet; wound dressing |
