| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 | 13권 2호, p.1515 |
| 발표분야 | 공정시스템 |
| 제목 | Finding Alternative 3-hydroxy Propionic Acid Pathways Using Generalized Enzyme Function Method |
| 초록 | At 2004, U.S. Department Of Energy reported twelve high-value added building blocks which can be yield from biomass and converted to various desirable chemicals subsequently. The building blocks are filtered by several screening steps and then twelve top value added chemicals are selected. Among them, we tried to find out the alternative synthetic route of 3-hydroxy propionic acid, which is existing only the pathway under the patent currently, using our computational framework which adopts Generalized Enzyme Function method. Finally we displayed the Gibbs Free Energy with Group Contribution method. The propanoate metabolism is considered as an original pathway and several alternatives are found; for example, Acetyl-CoA to the 3-HPA through enzyme reactions such as 4.1.1.9, 1.2.1.18, and 1.1.1.59. Acknowledgement This work was supported by Center for Ultramicrochemical Process Systems sponsored by KOSEF and the Korean Systems Biology Research Program of the Ministry of Science and Technology and by the BK21 project. Further supports from LG Chemicals Chair Professorship and IBM-SUR program are greatly appreciated. |
| 저자 | 조아연, 윤홍석, 이상엽, 박선원 |
| 소속 | 한국과학기술원 |
| 키워드 | Generalized Enzyme Function; Pathway Synthesis; 3HPA |
| 원문파일 | 초록 보기 |
