| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 | 12권 2호, p.1816 |
| 발표분야 | 생물화공 |
| 제목 | Retargeting of HER2 receptor mediated Adenoviral vectors : Adenovirus–Poly(Ethylene Glycol)-Herceptin conjugate |
| 초록 | To overcome the immune responses associated with Adenoviral vector, the surface of adenovirus (ADV) was modified with bifunctional poly(ethylene glycol) (PEG). And then, the surface of ADV-PEG derivatives was modified with Herceptin (Trastuzumab ; HER) again. The ADV coding the green fluorescent protein (GFP) gene was used to immobilize PEG or HER-PEG conjugate on the viral surface to comparatively evaluate their extents of retargeting, as compared to those of naked ADV. The ADV-PEG-HER showed a remarkably enhanced level of GFP expression than unmodified ADV or ADV-PEG for a HER2 receptor overexpressing cell line, but not for a HER2 receptor deficient several cell line. Acknowledgments : This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) |
| 저자 | 박효진, 김평환, 함승주 |
| 소속 | 연세대 |
| 키워드 | Adenovirus; PEG; Herceptin; Trastuzumab; gene therapy |
| 원문파일 | 초록 보기 |
