| 초록 |
As the human life span has been considerably extended, the rate of decrepitude-induced bone diseases like osteoporosis increases exponentially. Researches have been directed to develop biomaterials incoporated with drugs suitable for promotion of bone regeneration. Catechin is known to be effective in bone growth, arteriosclerosis, and inhibition of blood clots. In this study, we prepared microspheres in combination of gelatin and chitosan as a drug carrier. Catechin was incorporated in the microspheres at different concentrations. Morphology, surface charge, size, and chemical state were analyzed using scanning electronic microscopy, zeta potential, and fourier-transform infrared spectroscopy. In addition, catechin release kinetics was evaluated using high performance liquid chromatography. The effects of catechin incorporation on osteoblastic cell responses were examined in terms of proliferation and differentiation. |
