| 학회 |
한국공업화학회 |
| 학술대회 |
2005년 가을 (10/28 ~ 10/29, 건국대학교) |
| 권호 |
9권 2호 |
| 발표분야 |
콜로이드,계면화학 |
| 제목 |
Core-stabilized polymeric micelles by UV-photopolymerization |
| 초록 |
Poly(ethylene glycol)(PEG)-b-Poly(phenylalanine) copolymer has been synthesized and characterized. Polypeptide-based polymeric micelle has intensively been investigated as a drug delivery system not only because of its nanoscopic size also because of stability in human body. Although polymeric micelle show relatively slow dissociation behavior even below critical micelle concentration, it still needs to be stabilized. Upon intravenous injection polymeric micelle is faced to severe dilution condition and consequently the incorporated drug is precipitated in blood provoking harmful side effects. In this study the core of polymeric micelle is stabilized through UV-photopolymerization of polymerizable group at the end of hydrophoibic part and their stability is investigated. |
| 저자 |
정보경, 정재현, 김종득
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| 소속 |
한국과학기술원 생명화학공학과 |
| 키워드 |
polymeric micelle; photopolymerization; amphiphilic molecule
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| E-Mail |
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