| 초록 |
Catecholamine-based chemistry inspired from mussel adhesion can be applied to engineer biomaterial substrates and scaffolds to enhance the regenerative potential of stem cell therapy. In current study, dopamine, one of the well-known catecholamines, was used for modification of substrates and scaffolds for stem cell engineering and transplantation. The polymer substrates and hydrogels prepared via dopamine crosslinking significantly enhanced the viability and specific lineage differentiation of stem cells in vitro. More importantly, dopamine-modified biomaterial scaffolds improved the efficacy of stem cell transplantation in various diseased animal models including ischemic stroke, hindlimb ischemia, myocardial infarction, and calvarial bone defect. Mussel-inspired catecholamine functionalization can provide a versatile platform technology to develop functional, biocompatible scaffolds for improving therapeutic applications of stem cells. |
