| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
The Effect of The Additives on the Controlled Release of Sibutramine HCl Tablet |
| 초록 |
In this study, sibutramine HCl, appetite suppressants were prepared into tablet type with additives such as lactose monohydrate, MCC, and PVP K-25 to effective oral administration. We used the polyplasdone XL-10 as disintegrant. We compared the in vitro release behavior of sibutramine from the tablets according to additives with Reductila®. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimeter (DSC). FTIR and DSC results demonstrates that structure of drug was changed and crystallinity of drug was decreased. The dissolution rate of sibutramine HCl from tablet greatly increased in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8) in case of adding lactose monohydrate and PVP K-25. This study suggests that various pharmaceutical excipients could improve the sibutramine HCl release behaviors. This research was supported by WCU (R31-20029). |
| 저자 |
오명준, 심정보, 이정근, 배정우, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Sibutramine HCl; controlled -release; lactose monohydrate; PVP K-25
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| E-Mail |
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