| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Hyaluronic acid-conjugated phycocyanin nanoparticles for tumor targeted photodynamic therapy |
| 초록 |
Phycocyanin, a naturally derived biomaterial, has excellent photodynamic activity, anti-inflammatory and anti-cancer properties. To increase tumor specificity, we conjugated hyaluronic acid to phycocyanin nanoparticles (PC NPs) for tumor targeted photodynamic therapy. The hyaluronic acid-conjugated PC NPs (HA-PC NPs) had an average size of 289.19 ± 3.22 nm and a spherical shape with a rough surface. In FT-IR analysis, it was confirmed that the conjugation between hyaluronic acid and phycocyanin were successfully performed. Especially, the HA-PC NPs generated reactive oxygen species (ROS) by 635 nm laser irradiation. Furthermore, the HA-PC NPs showed ROS generation-mediated cytotoxicity under 635 nm laser irradiation. On the other hand, the cells pre-treated with HA showed low cytotoxicity under the laser irradiation after the treatment of the HA-PC NPs. Thus, we believe that HA-PC NPs could become an attractive photodynamic therapeutic agent for tumor targeted photodynamic therapy. |
| 저자 |
김민아1, 김현지1, 박지선1, 김진2, 윤순도1, 이창문1
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| 소속 |
1전남대, 2조선대 |
| 키워드 |
C-Phycocyanin; Hyaluronic acid; Photodynamic therapy; Reactive oxygen species
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| E-Mail |
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